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Adacel Vaccine FAQs
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Find answers to frequently asked questions about Adacel vaccine and pertussis

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Pertussis Adacel Vaccine CDCa Recommendations View All  

Pertussis

How common is pertussis?

It is estimated that up to 3.3 million cases of pertussis occur each year in adults and adolescents.2

Are infants at risk for pertussis?

Yes. Infants remain at risk for acquiring pertussis, especially when they are unimmunized or underimmunized (have not completed the primary series of DTaPb vaccinations). In fact, infants are at the highest risk for pertussis-related complications, including pneumonia, hospitalization, or death, which is why it is important to help prevent the spread of pertussis by vaccinating all close contacts of infants with a Tdap vaccine such as Adacel vaccine.9

Who transmits pertussis to infants?

Family members, especially parents, are the primary source of pertussis transmission to vulnerable infants when a source can be identified. An international, multicenter study concerning pertussis transmission showed that family members were the source of transmission in up to 83% of infant cases. Specifically, parents were the source of transmission in 55% of cases.3

  • International, multicenter study of 91 families3
  • Source cases were identified for 44 infants and described by relationship to the infant, age, and household status3

What is the adult immunization rate with Tdapc vaccine?

Many adults have not received Tdap vaccine. Despite CDC recommendations, only 8% of adults reported receiving Tdap vaccination from 2005 through 2010.23

Can health-care professionals transmit pertussis to patients or other health-care professionals?

Yes. Instances of transmission of pertussis from health-care professionals to other health-care professionals and patients have been well documented.18-20 For this reason, the CDC recommends a single Tdap booster dose for any health-care professional in contact with patients. This includes5

  • Health-care professionals who anticipate having close contact with infants <12 months of age
  • Health-care professionals employed by hospitals and in ambulatory-care settings who are in direct contact with patients

Adacel vaccine

What is the indication for Adacel vaccine?

Adacel vaccine is indicated for active booster immunization for the prevention of tetanus, diphtheria, and pertussis as a single booster dose in persons 11 through 64 years of age.

Are there risks associated with Adacel vaccine?

The most common local and systemic adverse reactions to Adacel vaccine include injection site pain, erythema, and swelling; headache, body ache, tiredness, and fever. Other adverse reactions may occur. A severe allergic reaction after a previous dose of Adacel vaccine or any other tetanus toxoid, diphtheria toxoid, or pertussis-containing vaccine, or to any component, or encephalopathy within 7 days of a previous dose of a pertussis-containing vaccine, is a contraindication.

The decision to give Adacel vaccine should be based on the potential benefits and risks; especially if Guillain-Barré syndrome has occurred within 6 weeks of receipt of a prior vaccine containing tetanus toxoid; if progressive or unstable neurologic disorders exist; or if adverse events have occurred in temporal relation to receipt of pertussis-containing vaccine. Persons who experienced Arthus-type hypersensitivity reactions following a prior dose of tetanus toxoid-containing vaccine should not receive Adacel vaccine less than 10 years since the last dose of tetanus toxoid-containing vaccine. The tip caps of the prefilled syringes may contain natural rubber latex, which may cause allergic reactions in latex sensitive individuals. Vaccination with Adacel vaccine may not protect all individuals.

Before administering Adacel vaccine, please click here to read full Prescribing Information.

Have studies been performed on concomitant use with other vaccines?

Data from interaction studies show that Adacel vaccine can be concomitantly administered with hepatitis B or trivalent inactivated influenza vaccines.17 However, the CDC states that, "... simultaneously administering the most widely used live and inactivated vaccines has produced seroconversion rates and rates for adverse reactions similar to those observed when the vaccines are administered separately."22

Should Adacel vaccine be administered to women who are pregnant?

Tdap vaccines are classified as Pregnancy Category C. Adacel vaccine is not indicated for use in pregnant women.

How soon after a Td immunization can Adacel vaccine be administered?

The Prescribing Information states that 5 years should elapse before the administration of Adacel vaccine after receiving a Td vaccination.17 According to the CDC, eligible adolescents and adults can receive Tdap vaccine regardless of the interval since they last received a vaccine containing tetanus or diphtheria toxoid.4
Click here to view the complete CDC recommendations.

What is the CPTg code for Adacel vaccine?

The CPT code for Adacel vaccine is 90715.
Click here for more information about reimbursement and coding.

What is the cost of Adacel vaccine?

The price you may pay for Adacel vaccine can be affected by ordering method, current promotions, or contracts between you and your office and sanofi pasteur. In order to get the accurate pricing, log onto VaccineShoppe.com® or call 1-800-VACCINE (1-800-822-2463).

Is immunization with Adacel vaccine reimbursable?

Many insurance providers reimburse immunization with Adacel vaccine. Contact your patients’ insurance providers to learn if Adacel vaccine is reimbursable under their plans.
Click here for more information about reimbursement and coding.

CDC recommendations

What are the current CDC recommendations for the use of Tdap vaccine in the prevention of pertussis?

Eligible adolescents and adults should receive a single booster dose of Tdap vaccine to replace a single dose of Tdd vaccine for active booster immunization against tetanus, diphtheria, and pertussis regardless of the interval since they last received a vaccine containing tetanus or diphtheria toxoid.4 Per ACIPe recommendations for individuals who have not received Tdap vaccine, a single Tdap booster dose is preferred for the following groups:

  • New parents5
  • Close contacts of infants5
  • Health-care workers5
  • Wound care (eg, urgent care, emergency department)5,21
  • Adolescents not yet vaccinated with Tdap21,f

Td is preferred for booster or wound care when Tdap is not indicated.5,21

Does the CDC recommend vaccinating adults to prevent transmission to infants?

Yes. Infants have the highest risk for morbidity and mortality associated with pertussis, therefore, adults (≤64 years of age) who have or anticipate having close contact with infants should receive a single dose of Tdap vaccine to protect against pertussis if they have not previously received Tdap vaccine.5 The spirit of these recommendations is to help prevent the spread of pertussis to vulnerable infants.

What are the CDC recommendations for women of childbearing age?

Ideally, women of childbearing age should be vaccinated with Tdap vaccine prior to pregnancy to prevent transmission of pertussis to their infants. If this is not done, vaccination with Tdap vaccine in the immediate postpartum period prior to discharge is recommended.6
For additional information please refer to the complete CDC recommendations for parents-to-be and postpartum women.

What are the CDC recommendations for immunization of health-care professionals with Tdap vaccine?

The CDC recommends a single Tdap booster dose for any health-care professional in contact with patients, including5

  • Health-care professionals who anticipate having direct contact with infants <12 months of age
  • Health-care professionals employed by hospitals and in ambulatory-care settings who are in direct contact with patients

a CDC = Centers for Disease Control and Prevention.

b DTaP = Diphtheria, tetanus, and acellular pertussis.

c Tdap = Tetanus, diphtheria, and acellular pertussis.

d Td = Tetanus and diphtheria.

e ACIP = Advisory Committee on Immunization Practices.

f 11 through 18 years of age.

g CPT = Current Procedural Terminology is a registered trademark of the American Medical Association.